ACS Chemical Neuroscience Molecule Spotlight on Gilenya (Fingolimod; FTY720)
نویسندگان
چکیده
منابع مشابه
Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies.
FTY720 (Fingolimod, Gilenya) is a sphingosine analog used as an immunosuppressant in multiple sclerosis patients. FTY720 is also a potent protein phosphatase 2A (PP2A)-activating drug (PAD). PP2A is a tumor suppressor found inactivated in different types of cancer. We show here that PP2A is inactive in polycythemia vera (PV) and other myeloproliferative neoplasms characterized by the expression...
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ژورنال
عنوان ژورنال: ACS Chemical Neuroscience
سال: 2011
ISSN: 1948-7193,1948-7193
DOI: 10.1021/cn100113g